Abstract Search

ea0022p431 | Endocrine tumours & neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

The Role of miRNA in reduction of type I 5’-iodothyronine deiodinase expression (D1) in renal clear cell carcinoma (ccRCC)

Boguslawska Joanna , Master Adam , Wojcicka Anna , Poplawski Piotr , Piekielko-Witkowska Agnieszka , Nauman Alicja

Type 1 deiodinase (D1) catalyses deiodination of tyroxine (T4), which leads either to synthesis of triiodothyronine or reverse triiodothyronine (rT3). Triiodothyronine (T3) regulates the expression of many tumour suppressor genes and oncogenes. We previously revealed that the expression of the whole pool of D1 transcripts was dramatically lowered in ccRCC tissues. One of the mechanism resulting in this aberration could be miRNA-mediated repress...

0 shares

ea0037gp.30.04 | Endocrine tumours and neoplasia – General | ECE2015

Re-introduction of type 1 iodothyronine deiodinase in renal cancer cells affects their migration and expression of adhesion-related genes

Poplawski Piotr , Boguslawska Joanna , Kedzierska Hanna , Rybicka Beata , Tanski Zbigniew , Visser Theo J , Nauman Alicja , Piekielko-Witkowska Agnieszka

Introduction: Type 1 iodothyronine deiodinase (DIO1) is one of the three enzymes regulating bioavailability of thyroid hormones. In contrast to DIO2 and DIO3, the specific cellular role of DIO1 remains controversial. Our previous studies showed that DIO1 expression in clear cell renal cell carcinoma (ccRCC) is decreased, followed by lowered intracellular T3 concentration. In this study we explored how re-introduction of DIO1 in ccRCC cells affects their mig...

0 shares

ePoster

Endocrine Abstracts

The Role of miRNA in reduction of type I 5’-iodothyronine deiodinase expression (D1) in renal clear cell carcinoma (ccRCC)

Re-introduction of type 1 iodothyronine deiodinase in renal cancer cells affects their migration and expression of adhesion-related genes

BiosciAbstracts